Molecular mimicry: An explanation for autoimmune diseases and infertility
نویسندگان
چکیده
منابع مشابه
[Molecular mimicry in the etiology of autoimmune diseases].
There are currently more than 80 different autoimmune diseases, affecting approximately 100 million people worldwide. The etiology of most autoimmune diseases is unknown. The highest incidence of these diseases is in the developed countries and they are more common in women than in men. Among the most often listed factors responsible for the onset of autoimmunity are genetic predisposition and...
متن کاملMolecular mimicry in autoimmune disease.
The origins of autoimmune disease are multifactorial. Environmental factors and a genetic predisposition result in tissue injury caused by autoreactive T cells or antibodies. Usually a single organ or individual cell type is aVected in the absence of gross abnormalities of the immune system. Autoimmune diseases tend to have long, asymptomatic prodromal periods and the initiating events leading ...
متن کاملMolecular mimicry and immune-mediated diseases.
Molecular mimicry has been proposed as a pathogenetic mechanism for autoimmune disease, as well as a probe useful in uncovering its etiologic agents. The hypothesis is based in part on the abundant epidemiological, clinical, and experimental evidence of an association of infectious agents with autoimmune disease and observed cross-reactivity of immune reagents with host 'self' antigens and micr...
متن کاملViral Infections and their Role in Autoimmune Diseases, with Emphasis on Mechanisms and Molecular Interactions
Introduction: The exact cause of most autoimmune diseases is still unknown; however, several factors play a role in causing or exacerbating autoimmune reactions. In addition to environmental factors such as bacterial, parasitic, fungal and viral infections, factors such as genetic characteristics and lifestyle are also included. Infections caused by viruses usually trigger a strong immune respo...
متن کاملPotential Role of Bacterial Infection in Autoimmune Diseases: A New Aspect of Molecular Mimicry
Molecular mimicry is an attractive mechanism for triggering autoimmunity. In this review, we explore the potential role of evolutionary conserved bacterial proteins in the production of autoantibodies with focus on granulomatosis with polyangiitis (GPA) and rheumatoid arthritis (RA). Seven autoantigens characterized in GPA and RA were BLASTed against a bacterial protein database. Of the seven a...
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ژورنال
عنوان ژورنال: Scandinavian Journal of Immunology
سال: 2018
ISSN: 0300-9475
DOI: 10.1111/sji.12697